Grb2^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Grb2^tm1Paw
• Name: growth factor receptor bound protein 2; targeted mutation 1, Tony Pawson
• MGI ID: MGI:2152451
• Synonyms: deltaGrb2, Grb2-
• Gene: Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Grb2^tm1Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51424
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 2 and 3 was replaced with a vector containing a neomycin selection cassette by homologous recombination. Immunoprecipitation and western blotting experiments on cell lysates derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:51424)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Grb2^tm1Paw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb2 Mutation: 43 strains or lines available

References

• Original: J:51424 Cheng AM, et al., Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell. 1998 Dec 11;95(6):793-803
• All: 14 reference(s)