Thim^{Tg(Myh6-TGFB1)1Ljf}
Transgenic Allele Detail

Summary

• Symbol: Thim^{Tg(Myh6-TGFB1)1Ljf}
• Name: thymoma insertional mutation; transgene insertion 1, Loren J Field
• MGI ID: MGI:2152519
• Synonyms: Thim^{Tg(Myhca-TGFB1)1Ljf}
• Gene: Thim Location: unknown Genetic Position: Chr2, cytoband F2-G
• Alliance: Thim^{Tg(Myh6-TGFB1)1Ljf} page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Thim^{Tg(Myh6-TGFB1)1Ljf} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFB1 (7040)

  Tgfb1

  (MGI:98725)

• Mutation details: A transgene containing a mutant form of human TGFB1 expressed under the control of a mouse alpha-cardiac myosin heavy chain promoter inserted into an unidentified locus in this line. Other transgenic lines generated using this construct did not correlate with the associated mutant phenotype of mice bearing the transgene in this line, suggesting that the transgene insertion was a mutational event. (J:59903)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thim Mutation: 0 strains or lines available

References

• Original: J:59903 Nakajima H, et al., Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation. Oncogene. 2000 Jan 6;19(1):32-8
• All: 1 reference(s)