Oca2^p-un+3J
Spontaneous Allele Detail

Summary

• Symbol: Oca2^p-un+3J
• Name: oculocutaneous albinism II; pink-eyed dilution unstable wild-type revertant 3 Jackson
• MGI ID: MGI:2152525
• Synonyms: p^un+3J
• Gene: Oca2 Location: Chr7:55889508-56186266 bp, + strand Genetic Position: Chr7, 33.44 cM
• Alliance: Oca2^p-un+3J page

Mutation origin

• Strain of Origin: C57BL/6J-Oca2^p-un

Mutation description

• Allele Type: Spontaneous
• Mutation: Deletion
• Mutation details: Removal, presumably by unequal homologous recombination, of an ~70 kb DNA duplication derived from retroviral-like intracisternal A particles that characterizes p^un, restores wild-type coat pigmentation. (J:3762)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oca2 Mutation: 70 strains or lines available

References

• Original: J:2108 Lyon MF, et al., Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6968-72
• All: 3 reference(s)