Rax^tm1Mjam
Targeted Allele Detail

Summary

• Symbol: Rax^tm1Mjam
• Name: retina and anterior neural fold homeobox; targeted mutation 1, Milan Jamrich
• MGI ID: MGI:2152531
• Synonyms: Rx^-
• Gene: Rax Location: Chr18:66067710-66072160 bp, - strand Genetic Position: Chr18, 39.03 cM
• Alliance: Rax^tm1Mjam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40830
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.7 kb region of the gene. The deleted region encodes the 5' portion of the transcript, corresponding to the protein initiation site and the N-terminal end of the homeodomain. (J:40830)

Expression

In Mice Carrying this Mutation:	46 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rax Mutation: 16 strains or lines available

References

• Original: J:40830 Mathers PH, et al., The Rx homeobox gene is essential for vertebrate eye development. Nature. 1997 Jun 5;387(6633):603-7
• All: 10 reference(s)