Ttc21b^aln
Chemically induced Allele Detail

Summary

• Symbol: Ttc21b^aln
• Name: tetratricopeptide repeat domain 21B; alien
• MGI ID: MGI:2152544
• Synonyms: alien, Alien, line 158
• Gene: Ttc21b Location: Chr2:66014671-66086961 bp, - strand Genetic Position: Chr2, 39.08 cM
• Alliance: Ttc21b^aln page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A developmental mutation identified in an ENU mutagenesis screen. An A to C mutation near the N-terminus converts the highly conserved glutamine at amino acid residue 15 to a proline. Western blot analysis indicates an absence of protein product in homozygotes. (J:133725)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttc21b Mutation: 52 strains or lines available

Notes

The Rab23 gene has been excluded as a candidate gene for this mutation.

References

• Original: J:75360 Herron BJ, et al., Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002 Feb;30(2):185-9
• All: 13 reference(s)