Adora2a^tm1Map
Targeted Allele Detail

Summary

• Symbol: Adora2a^tm1Map
• Name: adenosine A2a receptor; targeted mutation 1, Marc Parmentier
• MGI ID: MGI:2152583
• Synonyms: A2AAR^-, A2AKO, A2aR^-
• Gene: Adora2a Location: Chr10:75152711-75170618 bp, + strand Genetic Position: Chr10, 38.52 cM, cytoband B5.3
• Alliance: Adora2a^tm1Map page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42276
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 was replaced with a neomycin selection cassette. Northern blotting and in situ hybridization experiments confirmed that no detectable transcript is produced from this allele. (J:42276)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adora2a Mutation: 40 strains or lines available

References

• Original: J:42276 Ledent C, et al., Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor [see comments]. Nature. 1997 Aug 14;388(6643):674-8
• All: 73 reference(s)