Map2^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Map2^tm1Noh
• Name: microtubule-associated protein 2; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2152587
• Synonyms: map2-
• Gene: Map2 Location: Chr1:66214432-66481742 bp, + strand Genetic Position: Chr1, 33.49 cM
• Alliance: Map2^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71900
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette disrupted the exon that encodes the first microtubule-binding repeat. This exon corresponds to exon 15 of the human MAP2 gene. Western analysis did not detect protein in brain of eight week old homozygous mutant mice. (J:71900)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2 Mutation: 109 strains or lines available

References

• Original: J:71900 Teng J, et al., Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol. 2001 Oct 1;155(1):65-76
• All: 4 reference(s)