Gnai2^tm1Rmm
Targeted Allele Detail

Summary

• Symbol: Gnai2^tm1Rmm
• Name: G protein subunit alpha i2; targeted mutation 1, Richard M Mortensen
• MGI ID: MGI:2152617
• Synonyms: Galphai2-
• Gene: Gnai2 Location: Chr9:107491324-107512542 bp, - strand Genetic Position: Chr9, 58.43 cM
• Alliance: Gnai2^tm1Rmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68045
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 6. Western analysis confirmed the elimination of expression in homozygous mice and detected no compensatory expression changes in other pertussis toxin sensitive G proteins. (J:68045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnai2 Mutation: 56 strains or lines available

References

• Original: J:68045 Jain M, et al., Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H569-75
• All: 10 reference(s)