Gnao1^tm1Ejne
Targeted Allele Detail

Summary

• Symbol: Gnao1^tm1Ejne
• Name: guanine nucleotide binding protein, alpha O; targeted mutation 1, E J Neer
• MGI ID: MGI:2152683
• Synonyms: Galphao^-
• Gene: Gnao1 Location: Chr8:94537213-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^tm1Ejne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39013
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The beta-Geo cassette replaces exon 6. Immunoblot analysis did not detect protein in membrane or cytosolic fractions of brain from homozygous mutant mice. (J:39013)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:39013 Valenzuela D, et al., G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1727-32
• All: 7 reference(s)