Gnao1^tm1Lbi
Targeted Allele Detail

Summary

• Symbol: Gnao1^tm1Lbi
• Name: guanine nucleotide binding protein, alpha O; targeted mutation 1, Lutz Birnbaumer
• MGI ID: MGI:2152685
• Synonyms: Gnao1.1^tm1LBi, Go1alpha
• Gene: Gnao1 Location: Chr8:94537213-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^tm1Lbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46898
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The neo cassette was inserted into exon 6. No protein was detected in homogenates from homozygous targeted mice by ADP-ribosylation with pertussis toxin. (J:46898)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:46898 Jiang M, et al., Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3269-74
• All: 15 reference(s)