Psmb9^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Psmb9^tm1Stl
• Name: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:2152729
• Synonyms: LMP2 -
• Gene: Psmb9 Location: Chr17:34401006-34406347 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Psmb9^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21549
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.8-kb region, containing a 3' portion of exon 2, was replaced by a neomycin selection cassette. Western analysis of extracts from homozygous mutant mice showed that the encoded protein was absent and that Psmb8 protein levels were unaffected. (J:21549)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Psmb9^tm1Stl/Psmb9^tm1Stl	involves: 129P2/OlaHsd * C57BL/6
cx2	Psmb9^tm1Stl/Psmb9^tm1Stl Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
hematopoietic system	√
decreased CD8-positive, alpha-beta T cell number	√
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	√
immune system	√
decreased CD8-positive, alpha-beta T cell number	√
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	√
abnormal immune system physiology	√
increased susceptibility to Orthomyxoviridae infection	√
liver/biliary system	√
increased hepatocellular carcinoma incidence	√
muscle	√
increased leiomyosarcoma incidence	√
neoplasm	√	√
increased tumor incidence		√
increased hepatocellular carcinoma incidence	√
increased lymphoma incidence		√
increased sarcoma incidence		√
increased leiomyosarcoma incidence	√
increased lung tumor incidence	√
respiratory system	√
increased lung tumor incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Psmb9 Mutation: 24 strains or lines available

References

• Original: J:21549 Van Kaer L, et al., Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct;1(7):533-41
• All: 38 reference(s)