Psmb9^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Psmb9^tm1Stl
• Name: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:2152729
• Synonyms: LMP2 -
• Gene: Psmb9 Location: Chr17:34401006-34406347 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Psmb9^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21549
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.8-kb region, containing a 3' portion of exon 2, was replaced by a neomycin selection cassette. Western analysis of extracts from homozygous mutant mice showed that the encoded protein was absent and that Psmb8 protein levels were unaffected. (J:21549)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Psmb9 Mutation: 24 strains or lines available

References

• Original: J:21549 Van Kaer L, et al., Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct;1(7):533-41
• All: 38 reference(s)