Pdx1^tm1Ted
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm1Ted
• Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Thomas Edlund
• MGI ID: MGI:2152755
• Synonyms: Ipf1^-, pdx1^-
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm1Ted page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20779
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2, deleting sequences that encode the homeodomain, the splice acceptor site, and flanking intron sequences. Whole-mount immunohistochemical studies did not detect protein in homozygous mutant embryos. (J:20779)

Disease models

Expression

In Mice Carrying this Mutation:	14 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:20779 Jonsson J, et al., Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994 Oct 13;371(6498):606-9
• All: 19 reference(s)