Stil^tm1Mku
Targeted Allele Detail

Summary

• Symbol: Stil^tm1Mku
• Name: Scl/Tal1 interrupting locus; targeted mutation 1, Michael R Kuehn
• MGI ID: MGI:2152962
• Synonyms: SIL -/-
• Gene: Stil Location: Chr4:114857356-114900393 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Stil^tm1Mku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5, including two start codons, were were replaced with a PGK-neo cassette. Immunoblot analysis confirmed the absence of encoded protein in homozygous mutant mice. (J:55887)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stil Mutation: 45 strains or lines available

References

• Original: J:55887 Izraeli S, et al., The SIL gene is required for mouse embryonic axial development and left-right specification. Nature. 1999 Jun 17;399(6737):691-4
• All: 5 reference(s)