Col9a1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Col9a1^tm1Jae
• Name: collagen, type IX, alpha 1; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:2152964
• Gene: Col9a1 Location: Chr1:24216691-24291765 bp, + strand Genetic Position: Chr1, 9.95 cM
• Alliance: Col9a1^tm1Jae page

Histology of knee joint articular cartilage of wild-type control and Col9a1^tm1Jae/Col9a1^tm1Jae mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18628
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 8 in reverse transcriptional orientation relative to the gene. Northern blot analysis on RNA derived from E17.5 homozygous embryos demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts of rib cage and vertebral column from homozygous mice confirmed that no stable encoded protein was present. (J:18628)

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col9a1 Mutation: 56 strains or lines available

References

• Original: J:18628 Fassler R, et al., Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5070-4
• All: 20 reference(s)