Col10a1^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Col10a1^tm1Bhr
• Name: collagen, type X, alpha 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:2152965
• Gene: Col10a1 Location: Chr10:34265977-34273081 bp, + strand Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
• Alliance: Col10a1^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20879
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the third exon. This region encodes the triple helix collagenous domain. Northern blot, RNAse protection assays and RT-PCR analysis demostrated that no transcript was readily detected in RNA derived from limbs of homozygous mice. (J:20879)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col10a1 Mutation: 28 strains or lines available

References

• Original: J:20879 Rosati R, et al., Normal long bone growth and development in type X collagen-null mice. Nat Genet. 1994 Oct;8(2):129-35
• All: 4 reference(s)