Fga^tm1Jld
Targeted Allele Detail

Summary

• Symbol: Fga^tm1Jld
• Name: fibrinogen alpha chain; targeted mutation 1, Jay L Degen
• MGI ID: MGI:2152976
• Synonyms: Aalpha^-, fbg^-, Fbgalpha^-, Fg^-, Fib^-, Fib⁰
• Gene: Fga Location: Chr3:82933460-82940934 bp, + strand Genetic Position: Chr3, 36.96 cM, cytoband F1
• Alliance: Fga^tm1Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28436
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An HPRT minigene cassette was inserted into exon 1 in sequences corresponding to the the signal peptide sequence. Transcripts from this allele were not detected in total liver RNA derived from homozygous mice and an in vitro clotting assay demonstrated that no functional fibrinogen protein was present in plasma derived from homozygous mice. (J:28436)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fga Mutation: 44 strains or lines available

References

• Original: J:28436 Suh TT, et al., Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 1995 Aug 15;9(16):2020-33
• All: 66 reference(s)