Itgb4^tm1Son
Targeted Allele Detail

Summary

• Symbol: Itgb4^tm1Son
• Name: integrin beta 4; targeted mutation 1, Arnoud Sonnenberg
• MGI ID: MGI:2152982
• Synonyms: beta4-, beta4 null
• Gene: Itgb4 Location: Chr11:115865556-115899238 bp, + strand Genetic Position: Chr11, 80.91 cM
• Alliance: Itgb4^tm1Son page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33713
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin expression cassette replaced a genomic fragment containing exons 1 and 2. RT-PCR analysis demonstrated a lack of transcript in skin tissue of homozygous mice. (J:33713)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb4 Mutation: 107 strains or lines available

References

• Original: J:33713 van der Neut R, et al., Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet. 1996 Jul;13(3):366-9
• All: 5 reference(s)