Lama2^tm1Stk
Targeted Allele Detail

Summary

• Symbol: Lama2^tm1Stk
• Name: laminin, alpha 2; targeted mutation 1, Shin'ichi Takeda
• MGI ID: MGI:2153004
• Synonyms: dy^3K, dy3K, laminin211^-
• Gene: Lama2 Location: Chr10:26857281-27493021 bp, - strand Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
• Alliance: Lama2^tm1Stk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43145
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into an exon that encodes a part of domain IV of the laminin 2 chain. Western blot analysis of lysates derived from homozygous mice demonstrated that the protein was not present. (J:43145)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lama2 Mutation: 177 strains or lines available

References

• Original: J:43145 Miyagoe Y, et al., Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy. FEBS Lett. 1997 Sep 22;415(1):33-9
• All: 33 reference(s)