Eln^tm1Dyl
Targeted Allele Detail

Summary

• Symbol: Eln^tm1Dyl
• Name: elastin; targeted mutation 1, Dean Y Li
• MGI ID: MGI:2153007
• Synonyms: Eln^-
• Gene: Eln Location: Chr5:134731447-134776177 bp, - strand Genetic Position: Chr5, 74.76 cM
• Alliance: Eln^tm1Dyl page

Reduced vessel extensibility in the Fbln5^tm1Eno/Fbln5^tm1Eno and Eln^tm1Dyl/Eln⁺ carotid artery

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47771
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 4kb of gene sequence. In situ hybridization analysis showed the absence of the transcript in aortae of E17.5 homozygous mutant mice. The protein was not detectable in P0.5 aortae of homozygous mutant mice by hart staining. (J:47771)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eln Mutation: 40 strains or lines available

References

• Original: J:47771 Li DY, et al., Elastin is an essential determinant of arterial morphogenesis. Nature. 1998 May 21;393(6682):276-80
• All: 45 reference(s)