Vwf^tm1Wgr
Targeted Allele Detail

Summary

• Symbol: Vwf^tm1Wgr
• Name: Von Willebrand factor; targeted mutation 1, Denisa D Wagner
• MGI ID: MGI:2153009
• Synonyms: vWf-, VWF KO
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^tm1Wgr page

Spontaneous bleeding events in Vwf^tm1Wgr/Vwf^tm1Wgr mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49083
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into intron 5. Northern blot analysis revealed that no normal transcripts were present in homozygous mice, and immunofluorescence experiments demonstrated that the protein was not present in blood smears of homozygous mice. (J:49083)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 140 strains or lines available

References

• Original: J:49083 Denis C, et al., A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9524-9
• All: 98 reference(s)