Matn1^tm1Goe
Targeted Allele Detail

Summary

• Symbol: Matn1^tm1Goe
• Name: matrilin 1, cartilage matrix protein; targeted mutation 1, Paul F Goetinck
• MGI ID: MGI:2153042
• Synonyms: mat-1^tm1Goe, Matn1-
• Gene: Matn1 Location: Chr4:130671696-130682786 bp, + strand Genetic Position: Chr4, 64.09 cM
• Alliance: Matn1^tm1Goe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58843
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exon 4 and part of exon 5. In situ hybridization and immunohistochemical analysis in distal growth plates of E15 homozygous embryos demonstrated an absence of transcript and protein. (J:58843)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Matn1 Mutation: 20 strains or lines available

References

• Original: J:58843 Huang X, et al., Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Dev Dyn. 1999 Dec;216(4-5):434-41
• All: 4 reference(s)