Bgn^tm1Mfy
Targeted Allele Detail

Summary

• Symbol: Bgn^tm1Mfy
• Name: biglycan; targeted mutation 1, Marian F Young
• MGI ID: MGI:2153057
• Synonyms: Bgn^-/0, Bgn⁰, bgn-KO
• Gene: Bgn Location: ChrX:72527208-72539539 bp, + strand Genetic Position: ChrX, 37.33 cM, cytoband B
• Alliance: Bgn^tm1Mfy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49647
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in hemizyogous male mice and western blot analysis showed that the protein was not expressed in hemizygous male mice. (J:49647)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bgn Mutation: 9 strains or lines available

References

• Original: J:49647 Xu T, et al., Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998 Sep;20(1):78-82
• All: 65 reference(s)