Wnt1^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Wnt1^tm1Mrc
• Name: wingless-type MMTV integration site family, member 1; targeted mutation 1, Mario Capecchi
• MGI ID: MGI:2153126
• Synonyms: int-1-
• Gene: Wnt1 Location: Chr15:98687738-98691711 bp, + strand Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
• Alliance: Wnt1^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67737
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Tandem insertion of multiple copies of a neomycin resistance cassette into exon 2 by homologous recombination disrupted the gene. (J:67737)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt1 Mutation: 31 strains or lines available

References

• Original: J:67737 Thomas KR, et al., Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 1990 Aug 30;346(6287):847-50
• All: 2 reference(s)