Otx1^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Otx1^tm1Sia
• Name: orthodenticle homeobox 1; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:2153198
• Gene: Otx1 Location: Chr11:21944764-21952897 bp, - strand Genetic Position: Chr11, 14.1 cM
• Alliance: Otx1^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73592
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the exon that encodes the homeobox sequences of the protein. A mutant transcript consisting of neomycin sequences fused to 3' gene sequences was produced, but stop codons in the neomycin gene are predicted to prevent expression of protien from this allele. (J:73592)

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx1 Mutation: 86 strains or lines available

References

• Original: J:73592 Suda Y, et al., Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain. Genes Cells. 1996 Nov;1(11):1031-44
• All: 8 reference(s)