Otx1^{tm3(OTX2)Asim}
Targeted Allele Detail

Summary

• Symbol: Otx1^{tm3(OTX2)Asim}
• Name: orthodenticle homeobox 1; targeted mutation 3, Antonio Simeone
• MGI ID: MGI:2153200
• Synonyms: hOtx2¹
• Gene: Otx1 Location: Chr11:21944764-21952897 bp, - strand Genetic Position: Chr11, 14.1 cM
• Alliance: Otx1^{tm3(OTX2)Asim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52989
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A full length cDNA encoding the human OTX2 gene replaced a 2.3kb fragment containing exons 1 and 2. Correct expression of the human gene under the control of the Otx1 promoter was verified by in situ hybridization on sagittal sections of a E12.5 embryo. (J:52989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx1 Mutation: 86 strains or lines available

References

• Original: J:52989 Acampora D, et al., Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development. 1999 Apr;126(7):1417-26
• All: 2 reference(s)