Otx2^{tm1(OTX1)Asim}
Targeted Allele Detail

Summary

• Symbol: Otx2^{tm1(OTX1)Asim}
• Name: orthodenticle homeobox 2; targeted mutation 1, Antonio Simeone
• MGI ID: MGI:2153202
• Synonyms: hOtx1²
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^{tm1(OTX1)Asim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49817
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A human OTX1 cDNA with an SV40 poly(A) signal was fused to the Otx2 promoter elements, and part of exon 1 and exon 2 were deleted. This allele expresses the human OTX1 protein under Otx2 transcriptional control. (J:49817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:49817 Acampora D, et al., Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104
• All: 2 reference(s)