Fgfr1^tm5Jrt
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm5Jrt
• Name: fibroblast growth factor receptor 1; targeted mutation 5, Janet Rossant
• MGI ID: MGI:2153349
• Synonyms: n15
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm5Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49154
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• A loxP flanked neomycin cassette was inserted into intron 15. This is a hypomorphic allele. (J:49154)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:49154 Partanen J, et al., Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 1;12(15):2332-44
• All: 1 reference(s)