Fgfr1^tm6Jrt
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm6Jrt
• Name: fibroblast growth factor receptor 1; targeted mutation 6, Janet Rossant
• MGI ID: MGI:2153351
• Synonyms: Fgfr1^n15YF, n15, n15YF
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm6Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49154
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP flanked neomycin cassette was inserted into intron 15, and point mutations were introduced into the sequences encoding the one of the autophosphorylation sites and the PLCgamma binding site that altered the corresponding amino acids from tyrosine to phenylalanine. This is a hypomorphic allele. (J:49154)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:49154 Partanen J, et al., Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 1;12(15):2332-44
• All: 4 reference(s)