Fgfr1^tm6.1Jrt
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm6.1Jrt
• Name: fibroblast growth factor receptor 1; targeted mutation 6.1, Janet Rossant
• MGI ID: MGI:2153352
• Synonyms: Y766Fl
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm6.1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49154
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: This allele is a derivative of Fgfr1^tm6Jrt in which the loxP flanked neomycin cassette was removed via Cre mediated recombination by crossing Fgfr1^tm6Jrt mice with transgenic mice expressing Cre under the control of a CMV or beta-actin promoter. (J:49154)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:49154 Partanen J, et al., Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998 Aug 1;12(15):2332-44
• All: 5 reference(s)