Abl1^tm1Mlg
Targeted Allele Detail

Summary

• Symbol: Abl1^tm1Mlg
• Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Richard C Mulligan
• MGI ID: MGI:2153718
• Synonyms: abl^-, Abl², abl^m2, c-Abl-, c-abl²
• Gene: Abl1 Location: Chr2:31578388-31694239 bp, + strand Genetic Position: Chr2, 21.86 cM, cytoband B
• Alliance: Abl1^tm1Mlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72875
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 5 and part of exon 6 was replaced by a neomycin resistance cassette. These sequences encode the N-terminal part of the tyrosine kinase domain, including the nucleotide and ATP binding sites. (J:72875)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abl1 Mutation: 93 strains or lines available

References

• Original: J:72875 Tybulewicz VL, et al., Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991 Jun 28;65(7):1153-63
• All: 29 reference(s)