Abl2^tm1Ajk
Targeted Allele Detail

Summary

• Symbol: Abl2^tm1Ajk
• Name: ABL proto-oncogene 2, non-receptor tyrosine kinase; targeted mutation 1, Anthony J Koleske
• MGI ID: MGI:2153719
• Synonyms: arg -
• Gene: Abl2 Location: Chr1:156386356-156477138 bp, + strand Genetic Position: Chr1, 67.71 cM
• Alliance: Abl2^tm1Ajk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51887
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding amino acids 287-320, corresponding to the N-terminal portion of the kinase domain, were replaced with a neomycin selection cassette. Western blot analysis demonstrated the absence of the protein in tissue extracts derived from homozygous mice. (J:51887)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abl2 Mutation: 80 strains or lines available

References

• Original: J:51887 Koleske AJ, et al., Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron. 1998 Dec;21(6):1259-72
• All: 19 reference(s)