Tyr^cm1OR
Spontaneous Allele Detail

Summary

• Symbol: Tyr^cm1OR
• Name: tyrosinase; albino mottling 1, Oak Ridge
• MGI ID: MGI:2153728
• Synonyms: c^m1OR, Tyr^c-1R
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^cm1OR page

Mutation origin

• Strain of Origin: C3H/Rl

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Transposon insertion
• Mutation details: The mutation is a 5.4kb intracisternal A particle (IAP) element insertion upstream of the promoter. This is a hypomorphic allele; Northern blot analysis and RT-PCR results show that expression is at much lower levels in homozygous than in wild-type mice. (J:38209)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

References

• Original: J:38209 Wu M, et al., Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):890-4
• All: 1 reference(s)