Fgfr2^tm1Lni
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm1Lni
• Name: fibroblast growth factor receptor 2; targeted mutation 1, Peter Lonai
• MGI ID: MGI:2153799
• Synonyms: FGFR2-
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm1Lni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47643
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette in reverse orientation into exon 9, which encodes the IIIc Ig like loop of the ligand binding domain, replaced a ~10-13kb of sequence containing exons 10, 11, and part of exon 12. These exons encode the ATP binding site of the first kinase domain. (J:47643)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:47643 Arman E, et al., Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5082-7
• All: 3 reference(s)