Fgfr2^tm1Dsn
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm1Dsn
• Name: fibroblast growth factor receptor 2; targeted mutation 1, Clive Dickson
• MGI ID: MGI:2153810
• Synonyms: Fgfr2(IIIb)^-cond, Fgfr2-IIIb^flox
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm1Dsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59285
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon IIIb as follows: A loxP flanked neomycin reistance cassette was inserted in the intron 3' to exon IIIb and an additional loxP site was inserted into the intron 5' to exon IIIb. Correctly targeted ES cells were transiently transfected with a vector expressing Cre recombinase, and lines were selected that retained exon IIIb with flanking loxP sites, and used to inject blastocysts. (J:59285)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:59285 De Moerlooze L, et al., An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development. 2000 Feb;127(3):483-92
• All: 14 reference(s)