Fgfr2^tm2.2Dsn
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm2.2Dsn
• Name: fibroblast growth factor receptor 2; targeted mutation 2.2, Clive Dickson
• MGI ID: MGI:2153815
• Synonyms: FgfR2-IIIc^{deltaneo-flox}
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm2.2Dsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Fgfr2^tm2Dsn in which the neomycin and thymidine kinase sequences were deleted by crossing mice carrying the Fgfr2^tm2Dsn allele to mice which expresss Cre recombinase in the germ line. (J:72517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:72517 Hajihosseini MK, et al., A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3855-60
• All: 2 reference(s)