Fgfr2^tm3Dsn
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm3Dsn
• Name: fibroblast growth factor receptor 2; targeted mutation 3, Clive Dickson
• MGI ID: MGI:2153818
• Synonyms: FgfR2-IIIb^-lacZ
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm3Dsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67731
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutation: Insertion
• Mutation details: The IIIb isoform of the gene was specifically disrupted by inserting an IRES-lacZ gene cassette into exon IIIb. An adjacent loxP flanked neomycin cassette was removed via Cre mediated recombination by injecting fertilized heterozygous eggs with an vector expressing Cre recombinase. (J:67731)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	32 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:67731 Revest JM, et al., Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol. 2001 Mar 1;231(1):47-62
• All: 6 reference(s)