Ube2l3^m1Hrb
Transgenic Allele Detail

Summary

• Symbol: Ube2l3^m1Hrb
• Name: ubiquitin-conjugating enzyme E2L 3; mutation 1, Klaus Harbers
• MGI ID: MGI:2153819
• Synonyms: A6
• Gene: Ube2l3 Location: Chr16:16969879-17019363 bp, - strand Genetic Position: Chr16, 10.63 cM
• Alliance: Ube2l3^m1Hrb page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:36254
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Transgene description

• Transgene Type: Transgenic
• Mutation: Viral insertion
• Mutation details: J1 ES cells were infected with mp10 virus carrying a neomycin resistance gene. After selection, resistant ES cell colonies were analyzed for the presence of single-copy proviral DNA. A mouse line established from one of these cell lines was shown to have an insertion in intron 1 2kb downstream of exon 1. The insertion affects the transcription level of the gene as demonstrated by Northern blotting experiments. (J:36254)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2l3 Mutation: 45 strains or lines available

References

• Original: J:36254 Harbers K, et al., Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12412-7
• All: 1 reference(s)