Hand1^tm1Jcc
Targeted Allele Detail

Summary

• Symbol: Hand1^tm1Jcc
• Name: heart and neural crest derivatives expressed 1; targeted mutation 1, James C Cross
• MGI ID: MGI:2153823
• Synonyms: Hand1^null
• Gene: Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
• Alliance: Hand1^tm1Jcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46383
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the entire coding region of the gene was replaced by a neomycin resistance expression cassette. (J:46383)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand1 Mutation: 15 strains or lines available

Notes

Early mortality of homozygous embryos can be rescued by aggregation of mutant embryos with wild-type tetraploid embryos. By E10.5, embryos from tetrapoid chimeras die due to cardiac failure. The heart tubes show abnormal looping and ventricular myocardial differentiation. (J:46383)

References

• Original: J:46383 Riley P, et al., The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet. 1998 Mar;18(3):271-5
• All: 5 reference(s)