Hand1^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Hand1^tm1Eno
• Name: heart and neural crest derivatives expressed 1; targeted mutation 1, Eric N Olson
• MGI ID: MGI:2153824
• Synonyms: Hand1-, Hand1^KO, Hand1^lacZ
• Gene: Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
• Alliance: Hand1^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46384
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ reporter gene followed by a neomycin resistance expression cassette was inserted in frame at the position of the initiation codon. (J:46384)

Expression

In Mice Carrying this Mutation:	69 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hand1 Mutation: 15 strains or lines available

References

• Original: J:46384 Firulli AB, et al., Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70
• All: 11 reference(s)