Gata3^tm1Jeng
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1Jeng
• Name: GATA binding protein 3; targeted mutation 1, James Douglas Engel
• MGI ID: MGI:2153826
• Synonyms: Gata3^-, GATA-3^neo
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1Jeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28393
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 2, including the translational start site, was replaced by a neomycin resistance expression cassette. (J:28393)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 32 strains or lines available

References

• Original: J:28393 Pandolfi PP, et al., Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis [see comments]. Nat Genet. 1995 Sep;11(1):40-4
• All: 17 reference(s)