Rxra^tm4.1Ipc
Targeted Allele Detail

Summary

• Symbol: Rxra^tm4.1Ipc
• Name: retinoid X receptor alpha; targeted mutation 4.1, Pierre Chambon
• MGI ID: MGI:2153829
• Synonyms: Rxralpha^L-
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm4.1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67149
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Rxra^tm4Ipc in which exon 4 and flanking sequences including the thymidine kinase/ neomycin resistance cassette were removed in the germ line by crossing Rxra^tm4Ipc mice with transgenic mice expressing Cre recombinase under the control of a CMV promoter. (J:67149)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

References

• Original: J:67149 Li M, et al., RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development. 2001 Mar;128(5):675-88
• All: 1 reference(s)