Vcam1^tm1Dmil
Targeted Allele Detail

Summary

• Symbol: Vcam1^tm1Dmil
• Name: vascular cell adhesion molecule 1; targeted mutation 1, David Milstone
• MGI ID: MGI:2153831
• Synonyms: Vcam1^D4D, VCAM-1 D4D, Vcam1^tm2Cyb
• Gene: Vcam1 Location: Chr3:115903669-115923337 bp, - strand Genetic Position: Chr3, 50.17 cM
• Alliance: Vcam1^tm1Dmil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69597
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance expression cassette replaced exon 6, which encodes Ig domain 4 and one of two alpha4 integrin binding sites. Expression of all isoforms of the transcript were reduced in homozygous mice compared to wild-type. (J:69597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcam1 Mutation: 44 strains or lines available

References

• Original: J:69597 Cybulsky MI, et al., A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001 May;107(10):1255-62
• All: 4 reference(s)