Ascl2^tm1Alj
Targeted Allele Detail

Summary

• Symbol: Ascl2^tm1Alj
• Name: achaete-scute family bHLH transcription factor 2; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:2153832
• Synonyms: Mash-2-
• Gene: Ascl2 Location: Chr7:142520566-142523001 bp, - strand Genetic Position: Chr7, 88.08 cM
• Alliance: Ascl2^tm1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20553
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 510 bp genomic fragment corresponding to amino acids 20-189 of the encoded protein was replaced with an in-frame lacZ gene fused to the gene sequences and a neomycin resistance expression cassette. (J:20553)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl2 Mutation: 15 strains or lines available

References

• Original: J:20553 Guillemot F, et al., Essential role of Mash-2 in extraembryonic development. Nature. 1994 Sep 22;371(6495):333-6
• All: 8 reference(s)