Alcp4^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Alcp4^DBA/2J
• Name: alcohol preference locus 4, female specific; DBA/2J
• MGI ID: MGI:2153881
• QTL: Alcp4 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele decreases alcohol preference in female animals compared to C57BL/6J. (J:52086)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52086

Backcross progeny from two sets of crosses between (C57BL/6J x DBA/2J)F1 females x C57BL/6J males (N1 = 262 and N2 = 82) and C57BL/6J females x (C57BL/6J x DBA/2J)F1 males (N1= 73 N2 = 78) were analyzed for alcohol consumption. The difference in alcohol consumption between male and female backcross progeny is significant. Therefore sexes were analyzed separately using chi-square analysis to find quantitative trait loci (QTL). P<0.002 was obtained for linkage with D1Mit295 in females.

References

• Original: J:52086 Peirce JL, et al., A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mamm Genome. 1998 Dec;9(12):942-8
• All: 1 reference(s)