Bmd1^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Bmd1^CAST/EiJ
• Name: bone mineral density 1; CAST/EiJ
• MGI ID: MGI:2153899
• QTL: Bmd1 Location: Chr1:156602037-189303617 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 67.71 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone mineral density compared to C57BL/6J. (J:58152)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bmd1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58152

Bone mineral density (Bmd1) was measured as a quantitative trait (QTL) in a genome wide scan of 711 F2 mice in a genetic intercross involving C57BL/6J and CAST/Ei mice. C57BL/6J females express a low mineral bone density phenotype, alternatively CAST/Ei male express a high mineral bone density. Regression analysis was informative to show Bmd1 significantly associated with marker D1Mit15 within a defined QTL region bounded by markers D1Mit14 and D1Mit17. Due to the large size of the QTL region the authorsdid not suggest any candidate loci encoding for the bone mineral density phenotype.

References

• Original: J:58152 Beamer WG, et al., Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome. 1999 Nov;10(11):1043-9
• All: 1 reference(s)