Bpq2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bpq2^C57BL/6J
• Name: blood pressure QTL 2; C57BL/6J
• MGI ID: MGI:2153903
• QTL: Bpq2 Location: Chr1:156602037-156602216 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 67.71 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to salt-induced hypertension compared to A/J. (J:66987)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66987

C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 blood pressure QTLs to 5 mouse Chromosomes. Bpq1 and Bpq2 had main effects and mapped with markers on mouse Chromosome 1. Bpq1 mapped with D1Mit334 with an F value of 8.2 and a P value of 0.0046. Bpq2 mapped with D1Mit14 with an F value of 10.3 and a P value of 0.0015. Suggested candidates for Bpq1 were Slc4a3 and Nppc. Suggested candidates for Bpq2 were Ptgs2, Atp1b1, Ren1 and Ren2.

References

• Original: J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• All: 1 reference(s)