Bw5^DU6
QTL Variant Detail

Summary

• QTL variant: Bw5^DU6
• Name: body weight QTL 5; DU6
• MGI ID: MGI:2153914
• QTL: Bw5 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DU6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight compared to DUKs. (J:49578)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 1, Idh1 (29.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTLs mapping near Idh1 are Dbsty1 (21 cM),Insq2 (36 cM), Wt10q1 (25 cM), Wt6q1 (27 cM), Obq7 (28.7 cM), and Bw5 (36 cM). At another locus, Pea15 (93.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background and F11r (93.3 cM) showed differential expression between A/a and A/A^vy animals on the restricted diet. Diabesity QTL Obq9 (88.4 cM) maps near Pea15 and F11r.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49578

F2-intercross pedigree analysis of progeny from crosses between a single male of the outbred mouse line DU6 (selected for high body weight) and a DUKs female (a randomly mated control line) was used to map quantitative trait loci (QTLs). A QTL linked with body weight, Bw5, was placed at 14 cM on mouse Chromosome 1.

References

• Original: J:49578 Brockmann GA, et al., Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics. 1998 Sep;150(1):369-81
• All: 1 reference(s)