Bw36^DU6i
QTL Variant Detail

Summary

• QTL variant: Bw36^DU6i
• Name: body weight QTL 36; DU6i
• MGI ID: MGI:2153919
• QTL: Bw36 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight compared to DBA/2J. (J:66233)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bw36 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTLs effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The Cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i x DBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Body weight QTL 5 was mapped to mouse Chromosome 1 to cM position 36.

01.07.2015 - Curators Note: We had originally associated the body weight QTL 5 identified here, mapping to 36cM on Chr1 as Bw5. Bw5 was originally mapped using a different cross, an outbred crossof DU6 x DUK, in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Bw36.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)