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Ccrs1C57BL/6By
QTL Variant Detail
Summary
QTL variant: Ccrs1C57BL/6By
Name: corpus callosum hemisphere surface size 1; C57BL/6By
MGI ID: MGI:2153934
QTL: Ccrs1  Location: Chr1:156602037-156602216 bp  Genetic Position: Chr1, cM position of peak correlated region/allele: 67.71 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6By
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased corpus callosum hemisphere surface size compared to NZB/BlNj. (J:51052)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Significant interaction between Ccrs1 and Ccrs2 has been detected.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51052

65 loci with an average spacing approximately of 25 cM were screened in 284 (C57BL/6By x NZB/B1NJ)F2 animals for linkage with corpus callosum hemisphere surface size. NZB/B1NJ has smaller corpus callosum hemisphere surface size compared to C57BL/6By. QTLs affecting corpus callosum hemisphere surface size, Ccrs1 and Ccrs2, were identified on mouse Chromosome 1 and mouse Chromosome 4, respectively. Ccrs1 maps to 81.6 cM - 106.3 cM on Chromosome 1 with a peak LOD score of 4.23 at D1Mit14. Ccrs2 maps to 57.6 cM - 78.5 cM on Chromosome 4 with a peak LOD score of 2.72 at D4Mit12. Two-way analyses showed significant interaction between Ccrs1 and Ccrs2.

References
Original:  J:51052 Roy IL, et al., Quantitative trait loci implicated in corpus callosum midsagittal area in mice. Brain Res. 1998 Nov 16;811(1-2):173-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory