Cia9^NOD/ShiLtJ
QTL Variant Detail

Summary

• QTL variant: Cia9^NOD/ShiLtJ
• Name: collagen induced arthritis QTL 9; NOD/ShiLtJ
• MGI ID: MGI:2153955
• Synonyms: Cia9^NOD
• QTL: Cia9 Location: Chr1:45783900-189303617 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: NOD/ShiLtJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptiblity to collagen induced arthritis compared to C57BL/10SnSg.
• Inheritance: Other (see notes)

Notes

Cia9 follows an additive mode of inheritance and shows interaction with Cia2.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69981

353 (NOD.Q-H2^q x B10.Q-H2^q)F2 animals were screened for 155 polymorphic markers at an average spacing of 8.6 cM to identify loci associated with collagen induced arthritis. The NOD.Q-H2^q congenic is resistant to collagen induced arthritis compared to the B10.Q-H2^q congenic which develops arthritis of intermediate severity at an incidence of 50% following injection with type 2 collagen. (NOD.Q-H2^q x B10.Q-H2^q)F1 animals are resistant to arthritis.

A novel QTL for arthritis severity, Cia9, mapped to mouse Chromosome 1 from 81.6 cM - 106.3 cM with a peak LOD score = 5.6 at the Fcgr2b gene.

NOD.Q-H2^q-derived alleles at Cia9 contribute to additively inherited disease susceptibility.

A locus associated with arthritis severity and C5 serum levels, Cia23, mapped to mouse Chromosome 2 from 11 cM - 37 cM with a peak LOD score = 9.8 at the Hc (C5) gene. B10.Q-H2^qderived alleles at Cia23 contribute to additively inherited susceptibility to disease.

Cia23 and Cia9 show evidence of interaction: resistance to arthritis depends upon heterozygosity at Cia23 and homozygosity for B10.Q-H2^qderived alleles at Cia9. This interaction was confirmed using speed congenic strains carrying a NOD.Q-H2^q-derived allele at Cia23 on a B10.Q-H2^q background.

10.21.2014 Curator's Note: The authors refer to the Chromosome 2 QTL identified here as Cia2. However, because Cia2 was orginally mapped using a DBA/1J x SWR/J cross in J:53356 (1991) we consider the current study a separate mapping experiment and have named this QTL Cia23.

References

• Original: J:69981 Johansson AC, et al., Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes. Eur J Immunol. 2001 Jun;31(6):1847-56
• All: 3 reference(s)